Modification of Cisplatin Toxicity by Antioxidants
نویسندگان
چکیده
منابع مشابه
Cardiovascular baroreflex sensitivity attenuates by cisplatin-induced toxicity in rats
Introduction: Cisplatin (CP) therapy may disturb cardiovascular system control. The objective of this study was to find baroreflex sensitivity (BRS) in CP-induced nephrotoxicity in rats. Materials and Methods: Eighteen male and female Wistar rats were randomly assigned to two groups treated with CP (2.5 mg/kg/day) and the vehicle, for five consecutive days, and then were subjected to surgical ...
متن کاملRenoprotective effects of antioxidants against cisplatin nephrotoxicity
Nephrotoxicity is the major limitation for the clinical use of cisplatin as an anti-tumoural drug. Intracellular effects of cisplatin cause tubular damage and tubular dysfunction with sodium, potassium, and magnesium wasting. Renoperotective strategies against cisplatin are classified on 8 targets: 1) Decrease of cisplatin uptake by renal cell, 2) Inhibition of cisplatin metabolism, 3) Blocking...
متن کاملcardiovascular baroreflex sensitivity attenuates by cisplatin-induced toxicity in rats
introduction: cisplatin (cp) therapy may disturb cardiovascular system control. the objective of this study was to find baroreflex sensitivity (brs) in cp-induced nephrotoxicity in rats. materials and methods: eighteen male and female wistar rats were randomly assigned to two groups treated with cp (2.5 mg/kg/day) and the vehicle, for five consecutive days, and then were subjected to surgical p...
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Antioxidants are used on a very large scale to try to obtain and preserve optimal health. Nutraceuticals and food supplements frequently contain huge dosages of antioxidants. It is not generally recognised that high intake of antioxidants may also have adverse effects. Three antioxidants i.e. vitamin E, β-carotene and lipoic acid are used to illustrate general considerations on the toxicity of ...
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Cisplatin administration is frequently associated with renal insufficiency and tubular dysfunction. In this article, a case of massive cisplatin overdose as a result of an accidental substitution for carboplatin is reported. The patient developed oliguric renal failure, hepatotoxicity, ototoxicity, peripheral neuropathy, blindness, and severe myelosuppression. A therapeutic trial with N-acetylc...
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ژورنال
عنوان ژورنال: Japanese Journal of Pharmacology
سال: 1986
ISSN: 0021-5198
DOI: 10.1254/jjp.40.353